Cocktail of reactive species generated by cold atmospheric plasma: oral administration induces non-small cell lung cancer cell death

Abstract Non-small cell lung cancer (NSCLC) is the most common type of cancer, with 85% all reported as NSCLC. Moreover, there are no effective treatments in advanced This study shows for first time that oral administration plasma-treated water (PTW) can cure The cold plasma generates a cocktail reactive species, and this to mice showed toxicities even at highest dose PTW, after single repeated doses 28 d mice. In vivo studies reveal PTW favorable anticancer effects on chemo-resistant similarly gefitinib treatment reference drug NSCLC model. activities seem be involved inhibiting proliferation angiogenesis enhancing apoptosis cells. Interestingly, contributes enhanced immune response improved cachexia